Phineas Gage was an unfortunate man, but it's an ill wind that blows no good. His brain injury, sustained in 1848 when a tamping iron blew through his skull, left him alive but changed his personality.
Below is a digital reconstruction of his injury, showing what parts of his brain may have been affected by his accident. For more details on Gage and the reconstruction, check out this Guardian article by Mo Costandi. Even if it's not entirely accurate, it's still a beautiful graphic.
Found via It's Okay To Be Smart.